Salivary glands neoplasms represent a rare and diverse group of tumors with different characteristics. The prognosis for earlystage salivary gland cancer during 19831997 and latestage larynx cancer during 19741997 also demonstrated improvement 82. Algorithm for determining the etiology of salivary gland swelling. Doctors usually find salivary gland cancer when a patient shows up with the following symptoms.
Mar 18, 2019 salivary gland neoplasms make up 6% of all head and neck tumors. Here you can find more information on the different types of salivary gland cancers. Salivary gland tumors can arise in the three major paired salivary glands parotid, submandibular, and sublingual or in the minor salivary glands located throughout the upper aerodigestive tract around 50% of minor salivary glands are located in the hard palate1. Request pdf management of salivary gland cancer carcinomas of the salivary glands are uncommon representing only 26. Types of salivary gland cancer memorial sloan kettering. More than 30 percent of salivary gland cancers are thought to be this type. Malignant sgts represent 6% of head and neck cancers and 0. Adenoid cystic carcinoma is the commonest cancer in the submandibular and minor salivary glands, making up 4249% 14, 15. Multidisciplinary management of salivary gland cancers.
A superficial parotid gland tumor develops in the part of the gland thats over your facial nerve. The cancer is 2 centimeters the size of a shelled peanut or less in diameter and has not spread outside the salivary glands. Evaluation of patients with suspected salivary gland disorders figure 1. They are uncommon lesions that are distinct from other cancers of the head and neck and account for approximately 6% of neoplasms in that anatomic region. May 15, 2010 salivary gland and nasopharyngeal cancers were reported among 43 and 39 individuals, respectively. Older dogs and cats, poodle and spaniel breed dogs and siamese breed cats, and male cats are at a higher risk for salivary gland tumors.
Signs include swelling of the upper neck or ear base, halitosis, anorexia. You will learn about the different types of treatments doctors use for people with salivary gland cancer. Build on previous arrocases for salivary gland tumors. Many other noncancerous conditions may lead to a swollen salivary gland, including an infection or a stone in a salivary gland duct. Salivary gland tumors are treated surgically, often in conjunction with postoperative radiation therapy when the tumor is malignant.
A casecontrol study of risk factors for salivary gland. Lumps in the mouth or side of the face pain in the mouth, cheek, jaw, ear, or neck. Protocol for the examination of specimens from patients with carcinomas of the major salivary glands. Saliva has enzymes that help digest food and antibodies that help protect against infections of the mouth and throat. To assess the effect of various lifestyle risk factors on the risk of salivary gland cancer in canada using data from a populationbased casecontrol study. Salivary gland tumors represent a diverse group of neoplasms. Cancers that develop here often form tiny mucousfilled cysts. Pdf salivary gland tumours are a relatively rare and morphologically diverse group of lesions. For more information, see sarcoma adult soft tissue cancer. Salivary gland cancer from diagnosis to tailored treatment. Other types of cancer can also develop in the salivary glands, including acinic cell carcinoma, salivary duct carcinoma and primary salivary gland lymphoma. Systemic therapy for recurrent or metastatic salivary gland. Examination revealed a 4 cm parotid mass on the left. Risk factors include older age, radiation therapy treatment to head or neck, and being exposed to certain substances at work.
Multidisciplinary management of salivary gland cancers matthew j. Most salivary gland tumors are noncancerous benign. The following sources were used in the development of this schema seer extent of disease 1988. This chapter will provide an overview of the functions of saliva, the anatomy and. Parotid gland tumors are the most common type of salivary gland tumor. A deep lobe parotid gland tumor develops in the part of the gland thats under your facial nerve. Learn about the risk factors for salivary gland cancer and what you might be able to do to help lower your risk. Tests that examine the head, neck, and the inside of the mouth are. For salivary gland cancer, an endoscope is inserted into the mouth to look at the mouth, throat, and larynx.
For the management of abnormal cervical screening tests and cancer precursors. Salivary gland malignancies can occur throughout the upper aerodigestive tract but the majority of tumors occur in the parotid gland and other major salivary glands. Salivary gland tumors symptoms and causes mayo clinic. About your salivary gland surgery memorial sloan kettering. American cancer society, american society for colposcopy and cervical pathology, and american society for clinical pathology screening guidelines for the prevention and early detection of cervical cancer. As well as 3 major pairs of salivary glands we have over 600 smaller, minor salivary glands throughout the lining of the mouth and throat.
For accreditation purposes, this protocol should be used for the following procedures and tumor types. Adenoid cystic carcinoma is the second most common type of salivary gland cancer. The mandibular and parotid glands are most commonly affected. Cancers of the head and neck are identified by the area in which they begin. The anatomy and physiology of salivary glands benefits of saliva is that it is easily available for noninvasive collection and analysis. Data from a populationbased casecontrol study of 2 incident cases of salivary gland cancer and 3076 population controls were collected through selfadministered questionnaire and analysed using unconditional. Management of malignant tumors of the salivary glands. Xrays of the salivary gland called a sialogram to look for a tumor ultrasound, ct scan or mri to confirm that there is a growth, and to see if the cancer has spread to lymph nodes in the neck salivary gland biopsy or fine needle aspiration to determine whether the tumor is benign noncancerous or malignant cancerous. Being exposed to certain types of radiation may increase the risk of salivary cancer. Salivary gland and nasopharyngeal cancers in individuals with. Mucoepidermoid carcinoma is the most common type of salivary gland cancer. Cancers that start elsewhere and spread to the salivary glands are called secondary salivary gland cancers. Codes and coding instructions 3rd edition, 1998 cancer.
Cancer of the major salivary glands is a heterogeneous disease with a low overall incidence. Notes 80008700, 87208790, 8941, 8974, 8980, 8982, 97009701 c079 parotid gland c080 submandibular gland c081 sublingual gland c088 overlapping lesion of major salivary glands c089 major salivary gland, nos note 1. Oct 26, 2018 salivary gland tumors are rare, accounting for less than 10 percent of all head and neck tumors. Publications home of jama and the specialty journals of the. The mutations allow the cells to grow and divide rapidly. These cancers are treated based on where the cancer started. Salivary gland cancer is a type of head and neck cancer. The nccn guidelines panel for cervical cancer screening endorses the following guidelines for the prevention and early detection of cervical cancer.
June 2017 includes ptnm requirements from the 8th edition, ajcc staging manual. Our patient had a parotid mass for over 20years that had been stable in size until he began having tingling sensation in his cheek. People recovering from salivary gland cancer are encouraged to follow established guidelines for good health, such as not smoking, limiting alcohol, eating well, and managing stress. Signs of salivary gland cancer include a lump or trouble swallowing. Results of treatment for patients with salivary gland carcinoma have improved in recent years, most likely due to earlier diagnosis and the use of more effective locoregional therapy. Regular physical activity can help rebuild your strength and energy level. Salivary gland tumors sgts are rare neoplasms accounting for 0. If you are diagnosed with salivary gland cancer, the doctor needs to know the stage, or extent, of the disease to plan the best treatment. This clinically oriented book provides a comprehensive update on the biology, diagnosis, and treatment of salivary gland cancer.
Carcinomas of the major salivary glands constitute a heterogeneous group of rare malignant neoplasms, accounting for less than 5% of newly diagnosed head and neck cancers. Get detailed information about the treatment for newly diagnosed and recurrent salivary gland cancer in this summary for clinicians. Salivary gland cancer treatment options include surgery with or without postoperative radiation therapy, radiation therapy, and chemotherapy. Benign and malignant salivary gland tumors anticancer research.
Compared to the general population, individuals with aids had approximately twofold risks for salivary gland cancer sir 1. The heterogeneity of salivary malignancies is underscored by the world health organization classification, which categorizes these tumors into 24 subtypes with varying biologic. The most commonly reported salivary gland tumor is the adenocarcinoma. It can be used to monitor the presence and levels of hormones, drugs, antibodies, microorganisms and ions.
Pembrolizumab for the treatment of advanced salivary gland. This section explains the types of treatments that are the standard of care for salivary gland cancer. The cancer is larger than 2 centimeters but no more than 4 centimeters the size of a walnut in diameter. Find information about salivary gland cancer types and the latest research. The salivary glands make saliva and release it into the mouth. Salivary gland cancer is a rare disease in which malignant cancer cells form in the tissues of the salivary glands. Get an overview of salivary gland cancer and the latest key statistics in the us. Select a single response unless otherwise indicated. Salivary gland cancer an overview sciencedirect topics. Still in the us, carcinomas of the major salivary glands comprise 11% of oropharyngeal neoplasms. Salivary gland carcinomas sgcs are rare, accounting for salivary gland is the most common sign of a salivary gland tumor, but it doesnt mean you have cancer. Eight 16% of the 50 cases of parotid tumor were malignant. Staging is a careful attempt to find out whether the cancer has spread, and if so, to what parts of the body.
An endoscope is a thin, tubelike instrument with a light and a lens for viewing. Detailed information is presented on molecular characterization and radiological staging, and a series of treatmentrelated chapters describe the different surgical approaches to major and minor salivary gland cancer, including reconstructive surgery techniques, and. Doctors know salivary gland cancer occurs when some cells in a salivary gland develop mutations in their dna. The incidence of salivary gland neoplasms as a whole is approximately 5. Salivary gland cancer can start in any of the glands that make spit saliva. Salivary gland cancer is cancer that affects the parotid glands, sublingual glands, or the submandibular glands. There are numerous entities of salivary gland neoplasms and while.
102 1486 194 827 439 514 409 1443 283 26 903 636 224 1321 461 1531 1408 1396 1550 1072 186 1550 304 1440 1315 202 8 882 33 26 1022 1074 198 56 115 1307 549 41 1311 1318 1335 1321